Quantitative proteomic profiling of Cervicovaginal fluid from pregnant women with term and preterm birth
نویسندگان
چکیده
منابع مشابه
Cervicovaginal Fluid Acetate: A Metabolite Marker of Preterm Birth in Symptomatic Pregnant Women
Changes in vaginal microbiota that is associated with preterm birth (PTB) leave specific metabolite fingerprints that can be detected in the cervicovaginal fluid (CVF) using metabolomics techniques. In this study, we characterize and validate the CVF metabolite profile of pregnant women presenting with symptoms of threatened preterm labor (PTL) by both 1H-nuclear magnetic resonance spectroscopy...
متن کاملHuman cervicovaginal fluid biomarkers to predict term and preterm labor
Preterm birth (PTB; birth before 37 completed weeks of gestation) remains the major cause of neonatal morbidity and mortality. The current generation of biomarkers predictive of PTB have limited utility. In pregnancy, the human cervicovaginal fluid (CVF) proteome is a reflection of the local biochemical milieu and is influenced by the physical changes occurring in the vagina, cervix and adjacen...
متن کاملThe Prevalence of Vaginal Microorganisms in Pregnant Women with Preterm Labor and Preterm Birth
BACKGROUND To investigate the risk factors for vaginal infections and antimicrobial susceptibilities of vaginal microorganisms among women who experienced preterm birth (PTB), we compared the prevalence of vaginal microorganisms between women who experienced preterm labor (PTL) without preterm delivery and spontaneous PTB. METHODS Vaginal swab specimens from 126 pregnant women who experienced...
متن کاملChemokines Profiling of Patients with Preterm Birth
INTRODUCTION Nowadays it is thought that the main cause of premature birth is subclinical infection. However, none of the currently used methods provide effective prevention to preterm labor. The aim of the study was to determine the concentration of selected chemokines in sera of patients with premature birth without clinical signs of infection (n = 62), threatened preterm labor (n = 47), and ...
متن کاملImmunomodulatory factors in cervicovaginal secretions from pregnant and non-pregnant women: A cross-sectional study
BACKGROUND Pregnant women are at an increased risk for HIV infection due to unknown biological causes. Given the strong effect of sex-hormones on the expression of immunomuodulatory factors, the central role of mucosal immunity in HIV pathogenesis and the lack of previous studies, we here tested for differences in immunomuodulatory factors in cervico-vaginal secretions between pregnant and non-...
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ژورنال
عنوان ژورنال: Proteome Science
سال: 2021
ISSN: 1477-5956
DOI: 10.1186/s12953-021-00171-1